Piano prodigy Arima Kosei dominated the competition and all child musicians knew his name. But after his mother, who was also his instructor, passed away, he had a mental breakdown while performing at a recital that resulted in him no longer being able to hear the sound of his piano even though his hearing was perfectly fine. Even two years later, Kosei hasn't touched the piano and views the world in monotone, and without any flair or color.

The 17-year-old Izumi Shinichi lives with his mother and father in a quiet neighborhood in Tokyo. One night, worm-like aliens called Parasytes invade Earth, taking over the brains of human hosts by entering through their ears or noses. One Parasyte attempts to crawl into Shinichi's ear while he sleeps, but fails since he is wearing headphones, and enters his body by burrowing into his arm instead, taking over his right hand and is named Migi.

Yowamushi Pedal: Grande Road will pick up where season one left off and continue to follow Onoda, Naruko, Imazumi, and the entire Sohoku team as they compete in Day 3 of the Inter-High. Confirmed to be joining the returning members is Eikichi Machimiya of Hiroshima Kureminami Technical High School. His sole goal is to take down Hakone Academy.

Mihama Academy—on the surface, a closed learning environment established to nurture students who find themselves at odds with the world around them; in actuality, an orchard-cum-prison built to preserve fruit that has fallen too far from its tree.