The 17-year-old Izumi Shinichi lives with his mother and father in a quiet neighborhood in Tokyo. One night, worm-like aliens called Parasytes invade Earth, taking over the brains of human hosts by entering through their ears or noses. One Parasyte attempts to crawl into Shinichi's ear while he sleeps, but fails since he is wearing headphones, and enters his body by burrowing into his arm instead, taking over his right hand and is named Migi.

Mihama Academy—on the surface, a closed learning environment established to nurture students who find themselves at odds with the world around them; in actuality, an orchard-cum-prison built to preserve fruit that has fallen too far from its tree.

Selector Spread WIXOSS is the sequel to Selector Infected WIXOSS. WIXOSS is a card game that's popular with teenagers. Supposedly there exist "LRIG Cards," female character cards with wills of their own. Special girls can hear the voices of the LRIGs, and those who possess them are called Selectors. These Selectors have card battles in a dimension that other humans cannot access.